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DDx Episode 6

Sudoku seizures

9 minutes


Berend Feddersen, M.D.

Dr. Feddersen is a neurologist and professor at the University of Munich in the department of neurology and department of palliative medicine. His research interests include status epilepticus, hypoxia at high altitude, and outpatient palliative care. In his spare time, he enjoys juggling.

Peter Wolf, M.D.

Dr. Wolf is a neurologist and leading epilepsy researcher. As initiator of the European Epilepsy Academy Eurepa, he developed widespread activities for professional education in epilepsy, including the establishment of the distance education system Virepa. His research interests include all clinical and comprehensive care aspects of epilepsy.


A 25-year-old man is in a rehab hospital following a hypoxic brain injury he sustained in a skiing accident. Several weeks into his recovery, he begins to experience clonic seizures of his left arm from one unusual trigger: Sudoku. Listen to the case that caught the attention of neurologists around the world.

Video below copyright © (2015) American Medical Association. All rights reserved.

Feddersen B, Vollmar C, Rémi J, Stephan T, Flanagin VL, Noachtar S. Seizures From Solving Sudoku Puzzles. JAMA Neurol. 2015;72(12):1524–1526. doi:10.1001/jamaneurol.2015.2828